49ers
- Jimmy Garoppolo, QB Ankle OUT
- George Kittle, TE Knee OUT
- Raheem Mostert, RB Knee OUT
- Dre Greenlawl, LB Quad OUT
- Dee Ford, DE Back OUT
- Ahkello Witherspoon, CB Hamstring Questionable
Giants
- Adrian Colbert, DB Quad Doubtful
- Brandon Williams, CB Groin Questionable