Rams
- Cam Akers, RB Ribs OUT
- Darious Williams, CB Ankle Questionable
Bills
- Zach Moss, RB Toe OUT
- Dawson Knox, TE Concussion OUT
- Del’Shawn Phillips, LB Quad OUT
- Tremaine Edmunds, LB Shoulder Questionable
- Matt Milano, LB Hamstring Questionable
- Taron Johnson, CB Groin Questionable